NIMG-45. DISTINGUISHING PROGRESSION FROM PSEUDOPROGRESSION IN GLIOBLASTOMA: COMBINED USE OF 18F-FLUCICLOVINE PET AND MULTI-PARAMETRIC MRI
نویسندگان
چکیده
Abstract PURPOSE Differentiation of tumor progression (TP) from pseudoprogression (PsP) is a major unmet need in post-treatment glioblastoma (GBM). 18F-Fluciclovine synthetic amino acid PET radiotracer with higher uptake tissue vs. areas treatment-related change. We investigated the value for differentiating PsP TP independent and combination multi-parametric MRI. METHODS prospectively enrolled 30 patients GBM new or enlarging contrast-enhancing lesion on MRI after chemoradiotherapy who were planned surgical resection lesion. Patients underwent pre-operative Following surgery, relative percentages viable therapy-related changes observed histopathology quantified. categorized as if represented ≥ 50% specimen, mixed < > 10%, ≤ 10%. RESULTS 18 had TP, 4 8 PsP. TP/mixed significantly 40-50 minutes SUVmax (6.64 + 1.88 vs 4.11± 1.52, p=0.009) an cut-off 4.66 provided 90% sensitivity 83% specificity differentiation (AUC=0.856). A maximum cerebral blood volume (CBVmax) 3.67 71% (AUC=0.779). Combining 4.662 CBVmax 100% 80% (AUC=0.95). The time activity curve patterns to peaks not different between groups. Normalization parameters normal brain parenchyma helpful differentiate groups due variability subjects. CONCLUSION can accurately patients, even more accurate achieved when combined
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ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2022
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noac209.663